MYOFERLIN DEPLETION IN BREAST CANCER CELLS PROMOTES MESENCHYMAL TO EPITHELIAL SHAPE CHANGE AND STALLS INVASION.

Myoferlin depletion in breast cancer cells promotes mesenchymal to epithelial shape change and stalls invasion.

Myoferlin (MYOF) is a mammalian ferlin protein with homology to ancestral Fer-1, a nematode protein that regulates spermatic membrane fusion, which underlies the amoeboid-like movements of its sperm.Studies in muscle and endothelial cells have reported on the role of myoferlin in membrane repair, endocytosis, myoblast fusion, and the proper express

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Adaptive optimisation of explosive reactive armour for protection against kinetic energy and shaped charge threats

We evaluate an adaptive optimisation methodology, Bayesian optimisation (BO), for designing a minimum weight explosive reactive armour (ERA) for protection against a surrogate medium calibre kinetic energy (KE) long rod projectile and 7 Piece Queen Panel Bedroom Package surrogate shaped charge (SC) warhead.We perform the optimisation using a conven

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Comparison intercuspal mandible position twins

The twins are the miracle of fetal biology, medical reproductive challenge, the closest and most durable biological connection.The aim is to identify, evaluate and compare the type, number and location interjaw functional contacts in the intercuspal position of the mandible, with MZ monozygotic (identical) twins.Analysis of occlusal relationships i

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Clinical implications of advances in liver regeneration

Remarkable advances have been made recently in the area of liver regeneration.Even though liver regeneration after liver resection has been widely researched, new clinical applications have provided a better understanding of the process.Hepatic damage induces a process of regeneration that rarely occurs in normal undamaged liver.Many studies have c

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